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  • Influenza patients lie on cots at the U.S. Army Camp...

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    Influenza patients lie on cots at the U.S. Army Camp Hospital #45, Aix-les-Bains, France during the 1918 Spanish influenza outbreak.

  • Farm laborers receive masks before harvesting on April 28, 2020,...

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    Farm laborers receive masks before harvesting on April 28, 2020, in Greenfield, California.

  • Nursers work at the Intensive Treatment Unit at the Gilberto...

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    Nursers work at the Intensive Treatment Unit at the Gilberto Novaes Municipal Field Hospital on May 21 in Manaus, Brazil.

  • A medical worker shows the process for rapid coronavirus testing...

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    A medical worker shows the process for rapid coronavirus testing in Brooklyn in August.

  • A woman wearing a flu mask during the flu epidemic...

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    A woman wearing a flu mask during the flu epidemic which followed the First World War.

  • Members of the American Red Cross remove Spanish influenza victims...

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    Members of the American Red Cross remove Spanish influenza victims from a house in 1918.

  • People practicing social distancing enjoy the weather at Washington square...

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    People practicing social distancing enjoy the weather at Washington square park in San Francisco on July 31, 2020.

  • A police officer wears a branded face mask on Oct....

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    A police officer wears a branded face mask on Oct. 30 in Philadelphia.

  • Two men wearing and advocating the use of flu masks...

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    Two men wearing and advocating the use of flu masks in Paris during the Spanish flu epidemic in 1919.

  • Protesters hold signs against closing restaurants in Columbus, Ohio, in...

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    Protesters hold signs against closing restaurants in Columbus, Ohio, in November.

  • Influenza patients lie on cots at the Emergency Hospital in...

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    Influenza patients lie on cots at the Emergency Hospital in Camp Funston, Kansas, in 1918.

  • President Donald Trump has been criticized for his response to...

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    President Donald Trump has been criticized for his response to the COVID-19 pandemic. During a press briefing on April 23, 2020, he made controversial comments about how powerful the disinfectants are in fighting the virus, which made some people believe that he suggested people drink bleach. However, he said "I see the disinfectant, where it knocks it out in one minute. And is there a way we can do something like that, by injection inside or almost a cleaning, because you see it gets in the lungs and it does a tremendous number on the lungs, so it'd be interesting to check that, so that you're going to have to use medical doctors with, but it sounds interesting to me. So, we'll see, but the whole concept of the light, the way it kills it in one minute. That's pretty powerful."

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    Health personnel take a swab sample during a mass screening for coronavirus to test 25 percent of the population in Burgos, northern Spain, in November.

  • A "prone team," wearing personal protective equipment, prepares to turn...

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    A "prone team," wearing personal protective equipment, prepares to turn a COVID-19 patient onto his stomach in a Stamford Hospital intensive care unit, on April 24, in Stamford, Connecticut.

  • Commuters wear face masks as they exit a subway train...

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    Commuters wear face masks as they exit a subway train on April 17, 2020, in New York City.

  • Mexican medical doctor Estrella Gonzalez, 37, poses as she starts...

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    Mexican medical doctor Estrella Gonzalez, 37, poses as she starts her shift at the Fray Junipero Serra General Hospital in Tijuana, Mexico, on April 29, 2020.

  • Court is held outdoors in a park due to the...

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    Court is held outdoors in a park due to the epidemic in San Francisco in 1918.

  • During Spanish flu, an ad for OXO suggesting that if...

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    During Spanish flu, an ad for OXO suggesting that if you drink a cupful of OXO two or three times a day, it will protect you from the worst effects of the disease.

  • Alberta farmers in 1918 donned gauze masks to evade the...

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    Alberta farmers in 1918 donned gauze masks to evade the Spanish flu contagion rapidly sweeping west after World War I.

  • Precautions taken in Seattle would not permit anyone to ride...

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    Precautions taken in Seattle would not permit anyone to ride on the street cars without wearing a mask.

  • Remote students are shown on a screen behind UNLV Department...

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    Remote students are shown on a screen behind UNLV Department of Criminal Justice chairman and professor Dr. Joel Lieberman as he teaches Jury Decision Making, a criminal justice class at UNLV, amid the spread of the coronavirus in September.

  • An Army doctor sprays the throat of a patient as...

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    An Army doctor sprays the throat of a patient as a preventive treatment in 1918.

  • French soldiers of La Valbonne medical regiment set up a...

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    French soldiers of La Valbonne medical regiment set up a military field hospital at the Emile Muller Hospital in Mulhouse, eastern France, on March 22.

  • Masked doctors and nurses treat flu patients lying on cots...

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    Masked doctors and nurses treat flu patients lying on cots and in outdoor tents at a hospital camp during the influenza epidemic of 1918.

  • Medical workers attend to an ambulance gurney outside of Maimonides...

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    Medical workers attend to an ambulance gurney outside of Maimonides Medical Center in New York City in September.

  • Social distancing, one of the three main measures to help...

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    Social distancing, one of the three main measures to help slow the spread of coronavirus.

  • An American policeman wearing a mask.

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    An American policeman wearing a mask.

  • Women from the Department of War take 15-minute walks to...

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    Women from the Department of War take 15-minute walks to breathe in fresh air every morning and night to ward off the influenza virus during World War I.

  • A man spraying the top of a bus around 1919.

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    A man spraying the top of a bus around 1919.

  • Dr. Anthony Fauci, director of the National Institute of Allergy...

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    Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, is one of the lead members of the Trump administration's White House Coronavirus Task Force.

  • Los Angeles City Health Commissioner Luther M. Powers was instrumental...

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    Los Angeles City Health Commissioner Luther M. Powers was instrumental in lessening the effects of Spanish flu on the city.

  • Spanish influenza, also known as the 1918 flu, was a...

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    Spanish influenza, also known as the 1918 flu, was a deadly pandemic. During 1918-1919, more than 500 million people became infected around the world. The death toll was estimated to be at least 50 million worldwide. Nearly 675,000 of those occurred in the United States. A century later, the world was hit by another deadly pandemic. COVID-19 was first detected in Wuhan, China in December 2019.

  • St. Louis Red Cross Motor Corps on duty in October...

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    St. Louis Red Cross Motor Corps on duty in October 1918.

  • Advertisement for Milton sterilizing fluid was recommended for preventing and...

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    Advertisement for Milton sterilizing fluid was recommended for preventing and relieving influenza at a time when Spanish flu was rapidly spreading across the world.

  • This photo taken on July 20, 2020, shows a staff...

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    This photo taken on July 20, 2020, shows a staff member spraying disinfectant in a cinema in Wuhan, China.

  • Health worker and volunteer Luciano Marini receives a COVID-19 vaccine...

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    Health worker and volunteer Luciano Marini receives a COVID-19 vaccine in Brazil in August.

  • A doctor innoculates Major Peters of Boston against the Spanish...

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    A doctor innoculates Major Peters of Boston against the Spanish Influenza virus during the epidemic, around 1918.

  • Ray Bellia holds up N95 personal protective masks, used by...

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    Ray Bellia holds up N95 personal protective masks, used by medical and law enforcement professionals, in the warehouse of his Body Armor Outlet store, Wednesday, Dec. 9, 2020, in Salem, N.H. Bellia's store rapidly evolved into one of the nation's 20 largest suppliers of personal protective equipment to states this past spring, according to a nationwide analysis of state purchasing data by The Associated Press.

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Football coaches do it. President-elects do it. Even science-savvy senators do it. As cases of the coronavirus continue to surge on a global scale, some of the nation’s most prominent people have begun to double up on masks — a move that researchers say is increasingly being backed up by data.

Double-masking isn’t necessary for everyone. But for people with thin or flimsy face coverings, “if you combine multiple layers, you start achieving pretty high efficiencies” of blocking viruses from exiting and entering the airway, said Linsey Marr, an expert in virus transmission at Virginia Tech and an author on a recent commentary laying out the science behind mask-wearing.

Of course, there is a trade-off: At some point, “we run the risk of making it too hard to breathe,” she said. But there is plenty of breathing room before mask-wearing approaches that extreme.

A year into the COVID-19 pandemic, the world looks very different. More than 90 million confirmed coronavirus infections have been documented worldwide, leaving millions dead and countless others with lingering symptoms, amid ongoing economic hardships and shuttered schools and businesses. New variants of the virus have emerged, carrying genetic changes that appear to enhance their ability to spread from person to person.

And while several vaccines have now cleared regulatory hurdles, the rollout of injections has been sputtering and slow — and there is not yet definitive evidence to show that shots will have a substantial effect on how fast, and from whom, the virus will spread.

Through all that change, researchers have held the line on masks. “Americans will not need to be wearing masks forever,” said Dr. Monica Gandhi, an infectious disease physician at the University of California, San Francisco, and an author on the new commentary. But for now, they will need to stay on, delivering protection both to mask-wearers and to the people around them.

The arguments for masking span several fields of science, including epidemiology and physics. A bevy of observational studies have suggested that widespread mask-wearing can curb infections and deaths on an impressive scale, in settings as small as hair salons and at the level of entire countries.

One study, which tracked state policies mandating face coverings in public, found that known COVID cases waxed and waned in near-lockstep with mask-wearing rules. Another, which followed coronavirus infections among health care workers in Boston, noted a drastic drop in the number of positive test results after masks became a universal fixture among staff. And a study in Beijing found that face masks were 79% effective at blocking transmission from infected people to their close contacts.

Recent work by researchers like Marr is now pinning down the basis of these links on a microscopic scale. The science, she said, is fairly intuitive: Respiratory viruses like the coronavirus, which move between people in blobs of spittle and spray, need a clear conduit to enter the airway, which is crowded with the types of cells the viruses infect. Masks that cloak the nose and mouth inhibit that invasion.

The point is not to make a mask airtight, Marr said. Instead, the fibers that comprise masks create a haphazard obstacle course through which air — and any infectious cargo — must navigate.

“The air has to follow this tortuous path,” Marr said. “The big things it’s carrying are not going to be able to follow those twists and turns.”

Experiments testing the extent to which masks can waylay inbound and outbound spray have shown that even fairly basic materials, like cloth coverings and surgical masks, can be at least 50% effective in either direction.

Several studies have reaffirmed the notion that masks seem to be better at guarding people around the mask-wearer than mask-wearers themselves. “That’s because you’re stopping it right at the source,” Marr said. But, motivated by recent research, the Centers for Disease Control and Prevention has noted that there are big benefits for those who don masks as well.

The best masks remain N95s, which are designed with ultrahigh filtration efficiency. But they remain in short supply for health workers, who need them to safely treat patients.

Layering two less specialized masks on top of each other can provide comparable protection. Marr recommended wearing face-hugging cloth masks over surgical masks, which tend to be made with more filter-friendly materials but fit more loosely. An alternative is to wear a cloth mask with a pocket that can be stuffed with filter material, like the kind found in vacuum bags.

But wearing more than two masks, or layering up on masks that are already very good at filtering, will quickly bring diminishing returns and make it much harder to breathe normally.

Other tweaks can enhance a mask’s fit, such as ties that secure the fabric around the back of the head, instead of relying on ear loops that allow masks to hang and gape. Nose bridges, which can help the top of a mask to fit more snugly, offer a protective boost as well.

Achieving superb fit and filtration “is really simple,” Gandhi said. “It doesn’t need to involve anything fancy.”

No mask is perfect, and wearing one does not obviate other public health measures like physical distancing and good hygiene. “We have to be honest that the best response is one that requires multiple interventions,” said Jennifer Nuzzo, a public health expert at Johns Hopkins University.

Mask-wearing remains uncommon in some parts of the country, in part because of politicization of the practice. But experts noted that model behavior by the nation’s leaders might help to turn the tide. In December, President-elect Joe Biden implored Americans to wear masks for his first 100 days in office, and said he would make doing so a requirement in federal buildings and on planes, trains and buses that cross state lines.

A large review on the evidence behind masking, published this month in the journal PNAS, concluded that masks are a key tool for reducing community transmission and are “most effective at reducing spread of the virus when compliance is high.”

Part of the messaging might also require more empathy, open communication and vocal acknowledgment that “people don’t enjoy wearing masks,” Nuzzo said. Without more patience and compassion, simply doubling down on restrictions to “fix” poor compliance will backfire: “No policy is going to work if no one is going to adhere.”

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