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Oprah Winfrey is in final negotiations to join the cast of Disney’s “A Wrinkle in Time” adaptation that Ava Duvernay is on board to direct.

Jennifer Lee, who wrote and co-directed “Frozen” with Chris Buck, is penning the adaptation of Madeleine L’Engle’s book for Disney. The story follows children as they travel through time and visit strange worlds in order to find their missing scientist father.

“A Wrinkle in Time” is the first book in L’Engle’s “Time Quartet” series, which includes “A Wind in the Door,” “Many Waters” and “A Swiftly Tilting Planet.”

Winfrey will play Mrs. Which, one of the three Mrs. Ws that helps guide the children along their journey.

Winfrey and Duvernay have a relationship going back to “Selma,” which Winfrey appeared in and Duvernay directed. Sources say Duvernay always had Winfrey in mind for one of the three Mrs. Ws.

Winfrey is about to start filming on HBO’s “The Immortal Life of Henrietta Lacks.”

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She is repped by WME.