Images from the town appeared to show the rose window had been destroyed.
The church also included notable statues of the Archangel Gabriel, the Virgin Annunciate and images of monks in ornamental motif on one of its cornices.
Inside there are prized 15th-century paintings of the Annunciation and the Madonna and Child with two Angels (1492), attributed to a painter from the circle of Vittore Crivelli and Pietro Alemanno.
Damage to the area’s heritage is being assessed, according to reported.ly’s Marina Petrillo.
The Italian news agency Ansa estimates that the death toll has increased to 63, including that figure of at least 35 dead in Amatrice given by the local mayor. Ansa’s estimate also includes 11 people confirmed to be killed in Accumoli and another 10 victims in Pescara del Tronto.
As aftershocks continue, Italy’s National Institute of Geophysics and Volcanology has charted a summary of seismic activity in central Italy over the last 12 hours.
Its chief executive, Valerio Neri, said: “Children are the most vulnerable during emergencies and the impact of such events on their psyche is especially traumatic.
“To help children cope with the trauma, it is important that parents and carers find a way to stay close to them and make them feel that they are safe and secure. It is important talk and play with them and, above all, listen. It is also important to prevent your children watching television and seeing images of the disaster.”
Photographer Massimo Percossi captured what is likely to be one of the most enduring images of the earthquake. It shows an injured nun in Amatrice checking her mobile phone as she sat next to a victim laid out on ladder and covered in a blanket.